APJ receptor agonist 4
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APJ receptor agonist 4

SKU T39587-5 mg Category Brand:

2,032 CAD

Only 1000 item(s) left in stock.

Products Details

Product Description

– APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models and has shown an acceptable safety profile in preclinical toxicology studies. This compound effectively improves cardiac function, making it valuable for research into HF disease.

Web ID

– T39587

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C28H28ClFN6O3

References

– Meng W, et al. Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure. J Med Chem. 2021;64(24):18102-18113.

CAS Number

– 2135515-67-0

Molecular Weight

– C28H28ClFN6O3

SMILES

– CCc1cccc(CC)c1-n1c(O)c(C(=O)N2CCC(C2)c2ncc(Cl)cc2F)c(=O)nc1-c1ccn(C)n1

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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