Download Files:
Products Details
Product Description
– APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure[1].
Web ID
– HY-133036
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C31H26ClN3O3
References
– [1]Su S, Clarke A, et al. Biphenyl Acid Derivatives as APJ Receptor Agonists. J Med Chem. 2019;62(22):10456-10465.
CAS Number
– 2287153-38-0
Molecular Weight
– 524.01
SMILES
– O=C(C1=CC(C(N[C@@H](C2=CC=CC=C2)CCC)=O)=CC=[C@]1[C@]3=C(Cl)C=CC=C3C4=NC5=CC=CC=C5N4)O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Apelin Receptor (APJ)
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
