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AOH1160
SKU
HY-120836-10 mg
Category Reference compound
Tags Apoptosis;Cell Cycle/DNA Damage, Apoptosis;DNA/RNA Synthesis, Cancer
$60 – $450
Products Details
Product Description
– AOH1160 is a potent, first-in-class, orally available small molecule proliferating cell nuclear antigen (PCNA) inhibitor, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, causes cell-cycle arrest and induces apoptosis. AOH1160 selectively kills many types of cancer cells (mean GI50=330 nM) without causing significant toxicity to a broad range of nonmalignant cells[1].
Web ID
– HY-120836
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H20N2O3
References
– [1]Gu L, et al. The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res. 2018 Dec 1;24(23):6053-6065.
CAS Number
– 2089314-57-6
Molecular Weight
– 396.44
Compound Purity
– 99.30
SMILES
– O=C(C1=C2C=CC=CC2=CC=C1)NCC(NC3=CC=CC=C3OC4=CC=CC=C4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Apoptosis;DNA/RNA Synthesis
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.