Download Files:
Products Details
Product Description
– Antitumor agent-73 is a Diosgenin (HY-N0177) derivative, which inhibits STAT3 signaling and activates Pdia3/ERp57 exogenously. Antitumor agent-73 shows potent anti-tumor activity against various cancer cell lines, 7.9-341.7-fold stronger than Diosgenin[1].
Web ID
– HY-151286
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C50H82BrO4P
References
– [1]Wang L, et al. Synthesis and Antitumor Activity of Diosgenin Hydroxamic Acid and Quaternary Phosphonium Salt Derivatives. ACS Med Chem Lett. 2022 Apr 19;13(5):786-791.Â
CAS Number
– 2812356-72-0
Molecular Weight
– 858.06
SMILES
– C[C@]1(CC2)C(C[C@H]2OC(CCCC[P+](C3CCCCC3)(C4CCCCC4)C5CCCCC5)=O)=CC[C@]6([H])[C@]1([H])CC[C@@]7(C)[C@@]6([H])C[C@@]8([H])[C@]7([H])[C@H](C)[C@@]9(CC[C@H](CO9)C)O8.[Br-]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– STAT
Isoform
– STAT3
Pathway
– JAK/STAT Signaling;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
