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Product Description
– Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC50=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC50), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM[1].
Web ID
– HY-155846
Shipping
– Room temperature
Molecular Formula
– C29H26Cl2N4O3
References
– [1]Ibrahim TM, et al. Tetrahydrobenzo[h]quinoline derivatives as a novel chemotype for dual antileishmanial-antimalarial activity graced with antitubercular activity: Design, synthesis and biological evaluation. Eur J Med Chem. 2023 Sep 5;257:115534.
Molecular Weight
– 549.45
SMILES
– O=C(C1CCN(C(C)=O)CC1)NCC2=CC=C3CCC4=C(NC(C(C#N)=C4C5=C(Cl)C=CC(Cl)=C5)=O)C3=C2
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial;Parasite
Pathway
– Anti-infection
Product type
– Reference compound
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