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Products Details
Product Description
– Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 cells by destroying the integrity of fungal cell membranes. Antifungal agent 22 shows selective anti-Cryptococcus activity with good metabolic stability and low cytotoxicity[1].
Web ID
– HY-144632
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H26Cl3NOS
References
– [1]Li W, Yun Z, Ji C, et al. Discovery of Novel Sertraline Derivatives as Potent anti-<i>Cryptococcus</i> Agents.J Med Chem. 2022 Mar 6;10.1021/acs.jmedchem.1c01845.
CAS Number
– 2640054-39-1
Molecular Weight
– 446.86
SMILES
– ClC1=CC(C2C3=C(C(CC2)NCCC4CCOCC4)C=CS3)=CC=C1Cl.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Fungal
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
