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Products Details
Product Description
– Anticancer agent 81 (Compound 37b3) is an anticancer agent and can induce tumor cell cycle arrest and apoptosis. Anticancer agent 81 can be used as a payload to conjugate with Trastuzumab (HY-P9907) to obtain the antibody–agent conjugate (ADC) T-PBA. T-PBA maintained its mode of target and internalization ability of Trastuzumab[1].
Web ID
– HY-151207
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C46H46N6O5
References
– [1]Lai W, et al. Design, Synthesis, and Bioevaluation of a Novel Hybrid Molecular Pyrrolobenzodiazepine-Anthracenecarboxyimide as a Payload for Antibody-Drug Conjugate. J Med Chem. 2022 Aug 18.
CAS Number
– 2820286-56-2
Molecular Weight
– 762.89
SMILES
– O=C1N(CCN2CCN(CCCCCOC3=C(OC)C=C4C(N=C[C@@](CC(C5=CC=C(N)C=C5)=C6)([H])N6C4=O)=C3)CC2)C(C7=CC=CC8=CC9=CC=CC=C9C1=C78)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ADC Cytotoxin;Apoptosis
Pathway
– Antibody-drug Conjugate/ADC Related;Apoptosis
Product type
– ADC Related
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
