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Products Details
Product Description
– Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits NF-κB activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver[1].
Web ID
– HY-150587
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H30O3
References
– [1]Tran QTN, Tan DWS, Wong WSF, Chai CLL. From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action. Eur J Med Chem. 2020 Oct 15;204:112481.
Molecular Weight
– 306.44
SMILES
– CC(/C=C/C[C@@H]1C(CC[C@]2([H])[C@](C)(CO)[C@H](O)CC[C@@]12C)=C)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– ERK;NF-κB
Isoform
– ERK1;ERK2
Pathway
– MAPK/ERK Pathway;NF-κB;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
