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Products Details
Product Description
– Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model[1].
Web ID
– HY-146421
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H21FO6
References
– [1]Chen LZ, Wu J, Li K, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. Eur J Med Chem. 2020;206:112722.
CAS Number
– 2408836-40-6
Molecular Weight
– 424.42
SMILES
– COC1=CC2=C(C(OC)=C1)C(OC2C(C3=CC=C(C=C3)OCC4=CC=C(C=C4)F)O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– NF-κB;NO Synthase;Reactive Oxygen Species
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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