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Amodiaquine (dihydrochloride)
$50 – $55
Products Details
Product Description
– Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a Ki of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4][5].
Web ID
– HY-B1322B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H24Cl3N3O
Citations
– Oxid Med Cell Longev. 2021 Feb 10.|Pharmacol Res. 2023 Mar 20;106717.|Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.|Biol Pharm Bull. 2022 Feb 3.|Cell Rep. 2021 Apr 6;35(1):108959.|Metab Brain Dis. 2021 Jan 28.|Research Square Print. September 20th, 2022.
References
– [1]John R Horton, et al. Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. J Mol Biol. 2005 Oct 21;353(2):334-344.|[2]Chun-Hyung Kim, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61.|[3]Keita Kinoshita, et al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54.|[4]Akira Yokoyama, et al. Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84.|[5]M T HOEKENGA. The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine. Am J Trop Med Hyg. 1954 Sep;3(5):833-8.
CAS Number
– 69-44-3
Molecular Weight
– 428.78
Compound Purity
– 99.89
SMILES
– [H]Cl.[H]Cl.OC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1CN(CC)CC
Clinical Information
– Launched
Research Area
– Infection; Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 125 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Target
– Histone Methyltransferase;Parasite
Isoform
– Plasmodium
Pathway
– Anti-infection;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
