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Amlodipine (besylate)
$40 – $130
Products Details
Product Description
– Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer[1][2][3].
Web ID
– HY-B0317B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H31ClN2O8S
Citations
– Br J Pharmacol. 2021 Dec 3.|Dissolut Technol. 2021 Jun.|Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.|Cells. 2022 Oct 8;11(19):3156.|Exp Mol Med. 2021 Apr 2.|J Adv Res. 2023 Sep 13;S2090-1232(23)00257-6.|J Biochem Mol Toxicol. 2022 Oct 7;e23238.|J Chem Thermodyn. 2021, 106495.
References
– [1]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12.|[2]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87.|[3]Kishen G. Bulsara, et al. Amlodipine.|[4]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586.
CAS Number
– 111470-99-6
Molecular Weight
– 567.05
Compound Purity
– 99.92
SMILES
– O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC.O=S(C3=CC=CC=C3)(O)=O
Clinical Information
– Launched
Research Area
– Cancer; Cardiovascular Disease
Solubility
– DMSO : ≥ 45 mg/mL|H2O : 1 mg/mL (ultrasonic)
Target
– Calcium Channel
Isoform
– L-type calcium channel
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
