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Product Description
– Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
Web ID
– HY-B0285
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C6H8ClN7O
Citations
– ACS Nano. 2023 Apr 14.|Am J Transl Res. 2021 Jul 15;13(7):7538-7555.|Cell Commun Signal. 2023 May 4;21(1):99.|Cell Metab. 2022 Dec 6;34(12):2018-2035.e8.|Cell Physiol Biochem. 2018;51(6):2564-2574. |Commun Biol. 2022 Nov 14;5(1):1248.|Environ Sci Technol. 2021 Feb 11.|J Am Chem Soc. 2018 Dec 12;140(49):17234-17240.|J Nanobiotechnology. 2020 Jan 31;18(1):26.|J Pharmaceut Biomed. 2020, 113870.|Microb Pathog. 2019 Jul 18:103638. |Nanotechnology. 2018 Feb 23;29(8):085101.|Small Methods. 2020 Dec 18.|Theranostics. 2019 May 31;9(13):3732-3753.|Biomaterials. 2022 May;284:121529.|Br J Pharmacol. 2020 Aug;177(15):3473-3488. |Cell Rep. 2022 May 31;39(9):110880.|Int J Biol Macromol. 14 March 2022.|iScience. 19 October 2022, 105403.|J Ethnopharmacol. 2022 Mar 5;115171.|J Neuroinflammation. 2022 Feb 22;19(1):53.|Sci Total Environ. 2021, 146523.|Theranostics. 2020 May 17;10(15):6581-6598. |Transl Res. 2023 Sep 5;S1931-5244(23)00143-3.
References
– [1]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91.|[2]Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-26.|[3]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20(1):109-17.
CAS Number
– 2609-46-3
Molecular Weight
– 229.63
SMILES
– O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N
Clinical Information
– Launched
Research Area
– Metabolic Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Sodium Channel;TRP Channel
Pathway
– Apoptosis;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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