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Amikacin (hydrate)
$50 – $200
Products Details
Product Description
– Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin hydrate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin hydrate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin hydrate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2].
Web ID
– HY-B0509
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H28N2O5S
Citations
– Antibiotics (Basel). 2021 Sep 14;10(9):1110.|Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702.|Curr Microbiol. 2021 Dec 14;79(1):12.|J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858.|ACS Chem Biol. 2021 Dec 15.|Int J Antimicrob Agents. 2018 Aug;52(2):269-271.|Nat Commun. 2022 Mar 2;13(1):1116.|Int J Med Microbiol. 2023 Mar 28;313(2):151578.|J Antimicrob Chemother. 2020 Sep 1;75(9):2609-2615.
References
– [1]Ristuccia AM, et al. An overview of amikacin. Ther Drug Monit. 1985;7(1):12-25.|[2]Siân R Kitcher, et al. ORC-13661 Protects Sensory Hair Cells From Aminoglycoside and Cisplatin Ototoxicity. JCI Insight. 2019 Aug 8;4(15):e126764.|[3]Edson, R.S. and C.L. Terrell, The aminoglycosides. Mayo Clin Proc, 1999. 74(5): p. 519-28.
CAS Number
– 1257517-67-1
Molecular Weight
– 408.51
Compound Purity
– 98.0
SMILES
– O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CCN)=O)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO.[x].O
Clinical Information
– Launched
Research Area
– Infection; Cancer
Solubility
– DMSO : < 1 mg/mL|H2O : 100 mg/mL (ultrasonic;warming)
Target
– Antibiotic;Bacterial
Isoform
– Aminoglycoside
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
