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Amikacin (disulfate)
$50 – $312
Products Details
Product Description
– Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2].
Web ID
– HY-B0509B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H47N5O21S2
Citations
– ACS Chem Biol. 2021 Dec 15.|Int J Antimicrob Agents. 2018 Aug;52(2):269-271.|Nat Commun. 2022 Mar 2;13(1):1116.|Antibiotics (Basel). 2021 Sep 14;10(9):1110.|Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702.|Curr Microbiol. 2021 Dec 14;79(1):12.|J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858.|Int J Med Microbiol. 2023 Mar 28;313(2):151578.|J Antimicrob Chemother. 2020 Sep 1;75(9):2609-2615.
References
– [1]Edson, R.S. and C.L. Terrell, The aminoglycosides. Mayo Clin Proc, 1999. 74(5): p. 519-28.|[2]Siân R Kitcher, et al. ORC-13661 Protects Sensory Hair Cells From Aminoglycoside and Cisplatin Ototoxicity. JCI Insight. 2019 Aug 8;4(15):e126764.|[3]Ristuccia AM, et al. An overview of amikacin. Ther Drug Monit. 1985;7(1):12-25.
CAS Number
– 39831-55-5
Molecular Weight
– 781.76
Compound Purity
– 98.0
SMILES
– OS(O)(=O)=O.OS(O)(=O)=O.O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CCN)=O)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO
Clinical Information
– Launched
Research Area
– Infection; Cancer
Solubility
– DMSO : 1 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 100 mg/mL (ultrasonic)
Target
– Antibiotic;Bacterial
Isoform
– Aminoglycoside
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
