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Products Details
Product Description
– Amikacin (BAY 41-6551), a semisynthetic analog of kanamycin, is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin (BAY 41-6551) is ototoxic and nephrotoxic[1][2].
Web ID
– HY-B0509A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H43N5O13
Citations
– Int J Med Microbiol. 2023 Mar 28;313(2):151578.|J Antimicrob Chemother. 2020 Sep 1;75(9):2609-2615.|ACS Chem Biol. 2021 Dec 15.|Int J Antimicrob Agents. 2018 Aug;52(2):269-271.|Nat Commun. 2022 Mar 2;13(1):1116.|Antibiotics (Basel). 2021 Sep 14;10(9):1110.|Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702.|Curr Microbiol. 2021 Dec 14;79(1):12.|J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858.
References
– [1]Edson, R.S. and C.L. Terrell, The aminoglycosides. Mayo Clin Proc, 1999. 74(5): p. 519-28.|[2]Siân R Kitcher, et al. ORC-13661 Protects Sensory Hair Cells From Aminoglycoside and Cisplatin Ototoxicity. JCI Insight. 2019 Aug 8;4(15):e126764.|[3]Ristuccia AM, et al. An overview of amikacin. Ther Drug Monit. 1985;7(1):12-25.
CAS Number
– 37517-28-5
Molecular Weight
– 585.60
SMILES
– O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CCN)=O)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO
Clinical Information
– Launched
Research Area
– Infection; Cancer
Solubility
– 10 mM in DMSO|10 mM in H2O
Target
– Antibiotic;Bacterial
Isoform
– Aminoglycoside
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
