AMG 487
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AMG 487

SKU T10297L-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 77 CAD through 1,406 CAD

Products Details

Product Description

– AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.

Web ID

– T10297L

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C32H28F3N5O4

Citations

– 1. Dou Y, Nian Z, Wang D, et al.Reconstituted CD74+ NK cells trigger chronic graft versus host disease after allogeneic bone marrow transplantation.Journal of Autoimmunity.2024, 147: 103274.

References

– Johnson M, et al. Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3339-43.

CAS Number

– 473719-41-4

Molecular Weight

– C32H28F3N5O4

Compound Purity

– 0.9989

SMILES

– CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)[C@@H](C)N(Cc1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cc1

Target

– Others

Pathway

– Autophagy|||GPCR/G Protein|||Immunology/Inflammation

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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