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Product Description
– AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice[1].
Web ID
– HY-101699A
Shipping
– Room temperature
Molecular Formula
– C32H39F3N2O5S
References
– [1]Alykhan S Motani, et al. Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models. Pharmacol Res Perspect. 2013 Oct;1(1):e00003.
CAS Number
– 1001438-96-5
Molecular Weight
– 620.72
SMILES
– O=C(O)C1(CCCCC1)CCN2CC[C@@]3(CC4=C([C@@H]([C@]3(C2)[H])C)C(C=C(C=C5)C(F)(F)F)=C5N4)[H].O=S(C6=CC=CC=C6)(O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– MCHR1 (GPR24)
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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