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Products Details
Product Description
– Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC50 value of 10.5 μM in RAW264.7 cells.
Web ID
– HY-N10062
Shipping
– Room temperature
Molecular Formula
– C9H5Br2NO2
References
– [1]Maeyama Y, et al. Amakusamine from a Psammocinia sp. Sponge: Isolation, Synthesis, and SAR Study on the Inhibition of RANKL-Induced Formation of Multinuclear Osteoclasts. J Nat Prod. 2021 Oct 22;84(10):2738-2743.
CAS Number
– 2923661-84-9
Molecular Weight
– 318.95
SMILES
– BrC1=C2OCOC2=C(C3=C1C=CN3)Br
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– RANKL/RANK
Pathway
– NF-κB
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
