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AM251
Price range: 48 CAD through 376 CAD
Products Details
Product Description
– AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 nM).
Web ID
– T1915
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H21Cl2IN4O
Citations
– 1. Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15.
2. Bowden G D, Land K M, O’Connor R M, et al. High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth. International Journal for Parasitology: Drugs and Drug Resistance. 2018 Aprï¼›8(1): 137-144
3. Wang P P, Cheng X Q, Dou Z J, et al.Inhibiting the CB1 receptor in CIH-induced animal model alleviates colon injury.Applied Microbiology and Biotechnology.2024, 108(1): 380.
References
– Liao C, et al. Basic Clin Pharmacol Toxicol, 2004, 94(2), 73-78.
CAS Number
– 183232-66-8
Molecular Weight
– C22H21Cl2IN4O
Compound Purity
– 0.9788
SMILES
– CC1=C(N(N=C1C(NN2CCCCC2)=O)C3=C(Cl)C=C(Cl)C=C3)C4=CC=C(I)C=C4
Target
– Phospholipase
Pathway
– GPCR/G Protein|||Endocrinology/Hormones
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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