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Products Details
Product Description
– Alvameline (Lu25-109) is a partial M1 agonist and M2/M3 antagonist.
Web ID
– HY-101586
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C9H15N5
References
– [1]Jensen KG, et al. In vitro metabolism of the M1-muscarinic agonist 5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine by human hepatic cytochromes P-450 determined at pH 7.4 and 8.5. Drug Metab Dispos. 1999 Jan;27(1):125-32.|[2]Waldeck K, et al. Actions of the new antimuscarinic compound Alvameline on isolated human and pig detrusor. Neurourol Urodyn. 2002;21(1):92-8.|[3]Pike BR, et al. Chronic administration of a partial muscarinic M1 receptor agonist attenuates decreases in forebrain choline acetyltransferase immunoreactivity following experimental brain trauma. Exp Neurol. 1997 Sep;147(1):55-65.
CAS Number
– 120241-31-8
Molecular Weight
– 193.25
SMILES
– CN1CCC=C(C2=NN(CC)N=N2)C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– mAChR
Isoform
– mAChR3
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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