ALLO-2

SKU HY-117407-10 mg Category Tags , ,

$350$2,750

Products Details

Product Description

– ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1].

Web ID

– HY-117407

Storage Temperature

– -20°C, 3 years (Powder)

Shipping

– Blue Ice

Applications

– Cancer-programmed cell death

Molecular Formula

– C18H12F3N5O

References

– [1]Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.

CAS Number

– 1357350-60-7

Molecular Weight

– 371.32

Compound Purity

– 99.72

SMILES

– FC(F)(OC1=CC=C(C=C1)C2=NC(NC3=CC4=C(C=C3)NN=C4)=NC=C2)F

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 125 mg/mL (ultrasonic)

Target

– Smo

Pathway

– Stem Cell/Wnt

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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