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Aleplasinin
$380 – $3,200
Products Details
Product Description
– Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer’s disease research[1][2].
Web ID
– HY-14759
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C28H27NO3
References
– [1]Zhao J, Pei G. Evoking plasmin for beta-amyloid clearance. Cell Res. 2008 Aug;18(8):803-4.|[2]Kellici TF, Pilka ES, Bodkin MJ. Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19. Trends Pharmacol Sci. 2021 Jun;42(6):431-433.
CAS Number
– 481629-87-2
Molecular Weight
– 425.52
Compound Purity
– 99.26
SMILES
– O=C(O)C(C1=CN(CC2=CC=C(C(C)(C)C)C=C2)C3=C1C=C(C4=CC=CC(C)=C4)C=C3)=O
Clinical Information
– Phase 1
Research Area
– Neurological Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Amyloid-β;PAI-1
Pathway
– Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
