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Akt1&PKA-IN-2
$160 – $2,900
Products Details
Product Description
– Akt1&PKA-IN-2 ((R)-29) is an inhibitor of PKB/AKT with cyclin-dependent kinase 2 (CDK2) selectivity. Akt1&PKA-IN-2 inhibits AKT1, PKAa and CDK2a with IC50 values of 0.007 µM, 0.01 µM and 0.69 µM, respectively[1].
Web ID
– HY-148868A
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H17Cl2N3O
References
– [1]Ashton KS, et al. Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5191-6.
CAS Number
– 1334108-00-7
Molecular Weight
– 386.27
SMILES
– O=C(C1=CC2=C(C=NC=C2)C=C1)N[C@H](C3CNC3)C4=CC(Cl)=C(C=C4)Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt;CDK
Isoform
– Akt1;CDK2
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
