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Akt1&PKA-IN-1
$160 – $2,900
Products Details
Product Description
– Akt1&PKA-IN-1 is a potent dual Akt/PKA inhibitor with IC50 values of 0.03 , 0.11 μM, and 9.8 μM for PKAa, Akt, and CDK2, respectively. Akt1&PKA-IN-1 is selective for cyclin-dependent kinase 2 (CDK2)[1].
Web ID
– HY-148868
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H17Cl2N3O
References
– [1]Ashton KS, et al. Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5191-6.
CAS Number
– 1334107-58-2
Molecular Weight
– 386.27
SMILES
– O=C(C1=CC2=C(C=NC=C2)C=C1)N[C@@H](C3CNC3)C4=CC(Cl)=C(C=C4)Cl
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Akt;CDK;PKA
Isoform
– Akt;CDK2;PKA
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
