Agmatine (sulfate)

$50$80

Products Details

Product Description

– Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.

Web ID

– HY-101238

Storage Temperature

– 4°C (Powder, sealed storage, away from moisture)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C5H16N4O4S

References

– [1]Li G, et al. Agmatine: an endogenous clonidine-displacing substance in the brain. Science. 1994 Feb 18;263(5149):966-9.|[2]Reis DJ, et al. Is agmatine a novel neurotransmitter in brain? Trends Pharmacol Sci. 2000 May;21(5):187-93.|[3]Galea E, et al. Inhibition of mammalian nitric oxide synthases by agmatine, an endogenouspolyamine formed by decarboxylation of arginine. Biochem J. 1996 May 15;316 ( Pt 1):247-9.|[4]Morrissey JJ, et al. Agmatine activation of nitric oxide synthase in endothelial cells. Proc Assoc Am Physicians. 1997 Jan;109(1):51-7.|[5]Zomkowski AD, et al. Agmatine produces antidepressant-like effects in two models of depression in mice. Neuroreport. 2002 Mar 25;13(4):387-91.|[6]Ahn SS, et al. Effects of agmatine on blood-brain barrier stabilization assessed by permeability MRI in a rat model of transient cerebral ischemia. AJNR Am J Neuroradiol. 2015 Feb;36(2):283-8.|[7]Neis VB, et al. Agmatine enhances antidepressant potency of MK-801 and conventional antidepressants in mice. Pharmacol Biochem Behav. 2015 Mar;130:9-14.

CAS Number

– 2482-00-0

Molecular Weight

– 228.27

Compound Purity

– 98.0

SMILES

– NC(NCCCCN)=N.O=S(O)(O)=O

Clinical Information

– No Development Reported

Research Area

– Neurological Disease; Cancer

Solubility

– DMSO : 1 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : ≥ 100 mg/mL

Target

– Endogenous Metabolite;Imidazoline Receptor;NO Synthase

Isoform

– Human Endogenous Metabolite

Pathway

– Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling

Product type

– Natural Products

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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