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AGI-6780
Price range: 50 CAD through 2,128 CAD
Products Details
Product Description
– AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
Web ID
– T1809
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H18F3N3O3S2
Citations
– 1. Chen J, Yang J, Wei Q, et al. Identification of a selective inhibitor of IDH2/R140Q enzyme that induces cellular differentiation in leukemia cells. Cell Communication and Signaling. 2020, 18(1): 1-12
2. Tan Q, Zhang X, Li S, et al.DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis.Free Radical Biology and Medicine.2023
3. Yang J, Chen J, Chang J, et al.IDH2/R140Q mutation confers cytokine-independent proliferation of TF-1 cells by activating constitutive STAT3/5 phosphorylation.Cell Communication and Signaling.2024, 22(1): 116.
References
– Wang F, et al. Science. 2013, 340(6132), 622-666.
CAS Number
– 1432660-47-3
Molecular Weight
– C21H18F3N3O3S2
Compound Purity
– 0.9819
SMILES
– FC(F)(F)c1cccc(NC(=O)Nc2cc(ccc2-c2ccsc2)S(=O)(=O)NC2CC2)c1
Target
– Others
Pathway
– Metabolism
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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