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Product Description
– AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV)[1][2][3][4].
Web ID
– HY-13524A
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C16H15Cl2N3O2
References
– [1]Bojko A, et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50(2):186-95.|[2]Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580.|[3]Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215.|[4]Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6.
CAS Number
– 170449-18-0
Molecular Weight
– 352.22
SMILES
– COC1=CC2=NC=NC(NC3=CC=CC(Cl)=C3)=C2C=C1OC.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Metabolic Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– EGFR;HCV;Influenza Virus
Isoform
– EGFR/ErbB1/HER1
Pathway
– Anti-infection;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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