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Products Details
Product Description
– AF-DX 384 is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively)[1]. AF-DX 384 reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine[2].
Web ID
– HY-107652
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C27H38N6O2
References
– [1]Vannucchi MG, et al. Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats. Neuroscience. 1997 Aug;79(3):837-46. |[2]Dörje F, et al. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther. 1991 Feb;256(2):727-33.
CAS Number
– 118290-26-9
Molecular Weight
– 478.63
SMILES
– O=C1NC2=CC=CN=C2N(C3=C1C=CC=C3)C(NCCN4CCCCC4CN(CCC)CCC)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– mAChR
Isoform
– mAChR2;mAChR4
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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