Download Files:
Products Details
Product Description
– AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB[1].
Web ID
– HY-146399
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H19N3O4
References
– [1]Singh YP, et al. Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer’s disease. Eur J Med Chem. 2020 Jul 15;198:112257.
CAS Number
– 2761542-55-4
Molecular Weight
– 365.38
SMILES
– COC1=C(C=CC(/C=C/C(NCC(NC2=CC=C3NC=CC3=C2)=O)=O)=C1)O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Cholinesterase (ChE);ROS Kinase
Isoform
– AChE;BChE
Pathway
– Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
