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Products Details
Product Description
– ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). ABBV-467 induces apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma[1].
Web ID
– HY-149672
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C53H51Cl2FN6O9S
References
– [1]Yuda J, et al. Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond). 2023 Oct 25;3(1):154.
CAS Number
– 2287186-66-5
Molecular Weight
– 1037.98
SMILES
– O=C([C@@H](CC1=C(C)C(OC[C@@H](CN2CCN(C)CC2)OC3=C(Cl)C(C)=C4C(Cl)=C3)=CC=C1OCC5=NC(C6=CC=C(OC[C@@H]7OCCOC7)C=C6)=NC=C5)OC8=C9C4=C(C%10=CC=C(F)C=C%10)SC9=NC=N8)O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family
Pathway
– Apoptosis
Product type
– Reference compound
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