Download Files:
Products Details
Product Description
– ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). ABBV-467 induces apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma[1].
Web ID
– HY-149672
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C53H51Cl2FN6O9S
References
– [1]Yuda J, et al. Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond). 2023 Oct 25;3(1):154.
CAS Number
– 2287186-66-5
Molecular Weight
– 1037.98
SMILES
– O=C([C@@H](CC1=C(C)C(OC[C@@H](CN2CCN(C)CC2)OC3=C(Cl)C(C)=C4C(Cl)=C3)=CC=C1OCC5=NC(C6=CC=C(OC[C@@H]7OCCOC7)C=C6)=NC=C5)OC8=C9C4=C(C%10=CC=C(F)C=C%10)SC9=NC=N8)O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
