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Product Description
– A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a Ki of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with Kis of 37, 107 and 1467 nM, respectively[1].
Web ID
– HY-148076
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H26N6O2
References
– [1]Clive Mccarthy, et al. Antagonists of the adenosine a2a receptor. Patent WO2021224636 A1.
CAS Number
– 2738606-83-0
Molecular Weight
– 454.52
SMILES
– CC(C)(O)[C@H](C)NC(C1=NC2=C(C3=CC(C)=NC(C)=C3)C(C4=CC(C#N)=CC=C4)=NN2C=C1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Adenosine Receptor
Isoform
– Adenosine A1 receptor (A1R);Adenosine A2A receptor (A2AR);Adenosine A2B receptor (A2BR);Adenosine A3 receptor (A3R)
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
