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Product Description
– A1AR antagonist 3 (compound 13) is a selective adenosine 1 (A1) receptor antagonist with Kis of 9.69 nM and 0.529 nM for human A1 and rat A1, respectively. A1AR antagonist 3 can be used for researching neurological diseases[1].
Web ID
– HY-146456
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C25H20N2O3S
References
– [1]Abdelrahman A, et al. Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists. Eur J Med Chem. 2020;186:111879.
CAS Number
– 2413257-73-3
Molecular Weight
– 428.50
SMILES
– COC1=CC=C(C=C1)C(NC2=NC(C3=CC=CC=C3)=C(S2)C(C4=CC=C(C=C4)C)=O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Adenosine Receptor
Isoform
– Adenosine A1 receptor (A1R)
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
