Download Files:
A 438079
$83 – $670
Products Details
Product Description
– A 438079 is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
Web ID
– HY-15488
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C13H9Cl2N5
Citations
– Brain, Behavior, and Immunity. 2020 Aug;88:507-514.|Front Mol Neurosci. 2018 Nov 6;11:401.|Gen Physiol Biophys. 2019 Sep;38(5):407-416.|Int J Mol Sci. 2022 May 17;23(10):5586.|Med Sci Monit. 2020 Sep 21;26:e925491. |Neural Regen Res. 2021 Aug;16(8):1582-1591.|Purinergic Signal. 2023 Mar 1.|Cancer Immunol Res. 2020 Nov;8(11):1426-1439.|J Immunol. 2023 May 5;ji2200838.
References
– [1]McGaraughty S, et al. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007 Jun 8;146(4):1817-28.|[2]Marcellino D, et al. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson’s disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm (Vienna). 2010 Jun;117(6):681-7.|[3]Martins JP, et al. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012 Jan;165(1):183-96.|[4]Mesuret G, et al. CNS Neurosci Ther. 2014 Jun;20(6):556-64.
CAS Number
– 899507-36-9
Molecular Weight
– 306.15
Compound Purity
– 99.74
SMILES
– ClC1=C(Cl)C(C2=NN=NN2CC3=CC=CN=C3)=CC=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : 0.2 mg/mL (ultrasonic)
Target
– P2X Receptor
Isoform
– P2X7 Receptor
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
