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A 438079

SKU HY-15488-10 mg Category Reference compound Tags Membrane Transporter/Ion Channel, Neurological Disease, P2X Receptor

$83 – $670

Size10 mg

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Products Details

Product Description

– A 438079 is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

Web ID

– HY-15488

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C13H9Cl2N5

Citations

References

– [1]McGaraughty S, et al. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007 Jun 8;146(4):1817-28.|[2]Marcellino D, et al. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson’s disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm (Vienna). 2010 Jun;117(6):681-7.|[3]Martins JP, et al. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012 Jan;165(1):183-96.|[4]Mesuret G, et al. CNS Neurosci Ther. 2014 Jun;20(6):556-64.

CAS Number

– 899507-36-9

Molecular Weight

– 306.15

Compound Purity

– 99.74

SMILES

– ClC1=C(Cl)C(C2=NN=NN2CC3=CC=CN=C3)=CC=C1

Clinical Information

– No Development Reported

Research Area

– Neurological Disease

Solubility

– DMSO : 100 mg/mL (ultrasonic)|H2O : 0.2 mg/mL (ultrasonic)

Target

– P2X Receptor

Isoform

– P2X7 Receptor

Pathway

– Membrane Transporter/Ion Channel

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.