Download Files:
Products Details
Product Description
– 8-Bromo-ATP (8-Bromoadenosine 5′-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC50 of 23.1 μM[1][2][3].
Web ID
– HY-134262
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C10H15BrN5O13P3
References
– [1]Howson, W, et al. Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder). Eur. J. Med. Chem. 23(5), 433-439 (1988).|[2]P Champeil, et al. ATP regulation of sarcoplasmic reticulum Ca2+-ATPase. Metal-free ATP and 8-bromo-ATP bind with high affinity to the catalytic site of phosphorylated ATPase and accelerate dephosphorylation. J Biol Chem. 1988 Sep 5;263(25):12288-94.|[3]Li Wang, et al. Cationic phospholiposomes: efficient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cells. J Liposome Res. 2011 Dec;21(4):306-14.
CAS Number
– 23567-97-7
Molecular Weight
– 586.08
SMILES
– O=P(O)(O)OP(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(Br)=NC3=C(N)N=CN=C23)O1)(O)=O)(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– P2X Receptor
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
