740 Y-P
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740 Y-P

SKU TQ0003-1 mg Category Brand:

Price range: 142 CAD through 1,499 CAD

Products Details

Product Description

– 740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.

Web ID

– TQ0003

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C141H222N43O39PS3

Citations

– 1. Zuo X, Wei X, Ju C, et al. Protective Effect of Photobiomodulation against Hydrogen Peroxide-Induced Oxidative Damage by Promoting Autophagy through Inhibition of PI3K/AKT/mTOR Pathway in MC3T3-E1 Cells. Oxidative Medicine and Cellular Longevity. 2022 2. Rao Z, Li X, Zhang X, et al. Fengreqing Oral Liquid Exerts Anti-Inflammatory Effects by Promoting Apoptosis and Inhibiting PI3K/AKT and NF-κB Signaling Pathways. Frontiers in Pharmacology. 2022, 13: 824579-824579 3. Mai L, He G, Chen J, et al. Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells. Stem Cells International. 2021, 2021. 4. Zhao Y, Guo W, Gu X, et al. Repression of deoxynivalenol-triggered cytotoxicity and apoptosis by mannan/β-glucans from yeast cell wall: Involvement of autophagy and PI3K-AKT-mTOR signaling pathway. International Journal of Biological Macromolecules. 2020, 164: 1413-1421 5. Deng X, Liu X, Hu B, et al.Upregulation of MTHFD2 is associated with PD‑L1 activation in bladder cancer via the PI3K/AKT pathway.International Journal of Molecular Medicine.2023, 51(2): 1-15. 6. Guo A, Lin J, Zhong P, et al.Phellopterin attenuates ovarian cancer proliferation and chemoresistance by inhibiting the PU. 1/CLEC5A/PI3K-AKT feedback loop.Toxicology and Applied Pharmacology.2023: 116691. 7. Zhang K, Li J Y, Li K.Silencing PCMT1 enhances the sensitivity of breast cancer cells to paclitaxel through the PI3K/Akt/STMN1 pathway.Chemical Biology & Drug Design.2024, 103(6): e14559. 8. Zhu L, Meng Q, Qian W, et al.LARP3 inhibits the apoptosis of hepatocellular carcinoma via the ROS/PI3K/c-Fos axis.PloS one.2025, 20(1): e0317454. 9. Veratramine influences the proliferation of human osteosarcoma cells through modulation of the PI3K/AKT signaling cascade

References

– Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem Biophys Res Commun. 1998 Oct 9;251(1):148-52.

CAS Number

– 1236188-16-1

Molecular Weight

– C141H222N43O39PS3

Compound Purity

– 0.9857

SMILES

– C([C@@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC=2C=3C(NC2)=CC=CC3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@@H](CC4=CC=C(OP(=O)(O)O)C=C4)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CCSC)=O)CC(O)=O)=O)CCSC)=O)=O)=O)=O)CC(O)=O)=O)CO)=O)CCCCN)=O)CCCCN)=O)=O)CCCCN)=O)CCSC)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(N)=O)=O)CCC(N)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CCCCN)=O)[C@H](CC)C)=O)C=5C=6C(NC5)=CC=CC6

Pathway

– Autophagy|||PI3K/Akt/mTOR signaling

Product type

– Peptide

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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