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7,4′-Dihydroxyflavone
$60 – $350
Products Details
Product Description
– 7,4′-Dihydroxyflavone (7,4′-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1].
7,4′-Dihydroxyflavone (7,4′-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.
7,4′-Dihydroxyflavone (7,4′-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].
Web ID
– HY-N2609
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C15H10O4
References
– [1]Liu C, et al. The Flavonoid 7,4′-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts. Phytother Res. 2017 Mar;31(3):449-458.|[2]Liu C, et al. The Flavonoid 7,4′-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2. Phytother Res. 2015 Jun;29(6):925-32.
CAS Number
– 2196-14-7
Molecular Weight
– 254.24
Compound Purity
– 99.68
SMILES
– O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC=C13
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Endocrinology
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– CCR;NF-κB
Pathway
– GPCR/G Protein;Immunology/Inflammation;NF-κB
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
