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6,2′,4′-Trimethoxyflavone
$60 – $500
Products Details
Product Description
– 6,2′,4′-Trimethoxyflavone is a potent aryl hydrocarbon receptor (AHR) antagonist. 6,2′,4′-Trimethoxyflavone represses AHR-mediated gene induction[1].
Web ID
– HY-103220
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H16O5
References
– [1]Murray IA, et al. Antagonism of aryl hydrocarbon receptor signaling by 6,2′,4′-trimethoxyflavone [published correction appears in J Pharmacol Exp Ther. 2018 Nov;367(2):291]. J Pharmacol Exp Ther. 2010;332(1):135-144.|[2]Apaza T L, et al. Flavonoids of Tripodanthus acutifolius inhibit TNF-α production in LPS-activated THP-1 and B16-F10 cells. J Ethnopharmacol. 2019;242:112036.|[3]Chen WC, et al. Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain. J Neuroinflammation. 2019;16(1):187. Published 2019 Oct 12.
CAS Number
– 720675-74-1
Molecular Weight
– 312.32
Compound Purity
– 98.09
SMILES
– O=C1C=C(C2=CC=C(OC)C=C2OC)OC3=CC=C(OC)C=C13
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– DMSO : 5 mg/mL (ultrasonic)
Target
– Aryl Hydrocarbon Receptor
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
