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Products Details
Product Description
– 5(S)-HEPE, an active metabolite of eicosapentaenoic acid (EPA), is produced via the action of 5-lipoxygenase (5-LO). This compound functions as an agonist for G protein-coupled receptor 119 (GPR119), promoting cAMP accumulation in CHO-K1 cells expressing human GPR119 at 10 µM concentration. Additionally, 5(S)-HEPE enhances glucose-stimulated insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells at the same concentration. Notably, serum levels of 5(S)-HEPE are increased in hyperlipidemia patients.
Web ID
– T84567
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H30O3
CAS Number
– 92008-51-0
Molecular Weight
– C20H30O3
SMILES
– [C@@H](/C=C/C=CC/C=CC/C=CC/C=CCC)(CCCC(O)=O)O
Pathway
– Others
Product type
– Small Compound
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