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Products Details
Product Description
– 5-OH-HxMF is a hydroxylated polymethoxyflavone that has anti-inflammatory, anticancer, neurotrophic and neuroprotective activities[1][2][3].
Web ID
– HY-121711
Shipping
– Room temperature
Molecular Formula
– C21H22O9
References
– [1]Hui-Chi Lai, et al. Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells. PLoS One. 2011;6(11):e28280. |[2]Min Jeong Kim, et al. Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone via NF-κB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage. Mol Med Rep. 2014 Apr;9(4):1197-203.|[3]Ching-Shu Lai, et al. Inhibitory effect of citrus 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice. Carcinogenesis. 2007 Dec;28(12):2581-8.
CAS Number
– 1176-88-1
Molecular Weight
– 418.39
SMILES
– O=C1C(OC)=C(OC2=C1C(O)=C(C(OC)=C2OC)OC)C3=CC=C(C(OC)=C3)OC
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
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