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Products Details
Product Description
– 4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1].
Web ID
– HY-109583
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H31NO3
References
– [1]Villani MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.|[2]Villani
MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite,
induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive
and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.
CAS Number
– 865536-65-8
Molecular Weight
– 405.53
SMILES
– OC(C=C1)=CC=C1NC(/C=C(C)/C=C/C=C(C)/C=C/C(C(C)(CC2)C)=C(C)C2=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Drug Metabolite;Reactive Oxygen Species
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
