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4′-Hydroxy diclofenac
SKU
HY-15550-1 mg
Category Reference compound
Tags Drug Metabolite, Inflammation/Immunology; Neurological Disease, Metabolic Enzyme/Protease
$240 – $600
Products Details
Product Description
– 4′-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4′-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].
Web ID
– HY-15550
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C14H11Cl2NO3
References
– [1]J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8.|[2]Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar;43(3):309-16.
CAS Number
– 64118-84-9
Molecular Weight
– 312.15
Compound Purity
– 99.62
SMILES
– O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=C(O)C=C2Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Drug Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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