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Products Details
Product Description
– 3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of approximately 132 nM in culture medium and 9.8 μM in plasma. Although less selective, it shows greater cytotoxicity compared to PKC412[1].
Web ID
– T12610L
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C35H30N4O5
References
– Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108(10):3477-83.
CAS Number
– 179237-49-1
Molecular Weight
– C35H30N4O5
SMILES
– CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4C(O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
Target
– Others
Pathway
– Tyrosine Kinase/Adaptors|||Angiogenesis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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