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Products Details
Product Description
– 2MD is an orally active vitamin D analog. 2MD stimulates periosteal bone formation and decreases trabecular bone resorption. Thus 2MD restores trabecular and cortical bone mass and strength. 2MD also regulates intraocular pressure (IOP)-relative genes and reduces IOP in non-human primates[1][2].
Web ID
– HY-148698
Shipping
– Room temperature
Molecular Formula
– C27H44O3
References
– [1]Kutuzova GD, et al. 1α,25-Dihydroxyvitamin D(3) and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), suppress intraocular pressure in non-human primates. Arch Biochem Biophys. 2012 Feb 1;518(1):53-60. |[2]Ke HZ, et al. A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia. J Bone Miner Res. 2005 Oct;20(10):1742-55.
CAS Number
– 213250-70-5
Molecular Weight
– 416.64
SMILES
– C[C@@]12[C@](CC[C@]2([H])[C@@H](C)CCCC(C)(O)C)([H])/C(CCC1)=C/C=C3C[C@H](C([C@@H](C3)O)=C)O
Clinical Information
– Phase 1
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– VD/VDR
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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