Download Files:
Products Details
Product Description
– 2MD is an orally active vitamin D analog. 2MD stimulates periosteal bone formation and decreases trabecular bone resorption. Thus 2MD restores trabecular and cortical bone mass and strength. 2MD also regulates intraocular pressure (IOP)-relative genes and reduces IOP in non-human primates[1][2].
Web ID
– HY-148698
Shipping
– Room temperature
Molecular Formula
– C27H44O3
References
– [1]Kutuzova GD, et al. 1α,25-Dihydroxyvitamin D(3) and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), suppress intraocular pressure in non-human primates. Arch Biochem Biophys. 2012 Feb 1;518(1):53-60. |[2]Ke HZ, et al. A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia. J Bone Miner Res. 2005 Oct;20(10):1742-55.
CAS Number
– 213250-70-5
Molecular Weight
– 416.64
SMILES
– C[C@@]12[C@](CC[C@]2([H])[C@@H](C)CCCC(C)(O)C)([H])/C(CCC1)=C/C=C3C[C@H](C([C@@H](C3)O)=C)O
Clinical Information
– Phase 1
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– VD/VDR
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
