20S Proteasome activator 1

SKU T63321-5 mg Category Small Compound Brand: TargetMol

Price range: 102 CAD through 861 CAD

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Products Details

Product Description

– 20S Proteasome activator 1 is a 20S proteasome activator with IC50 values of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites, and 1.8 μM for caspase sites. It prevents the accumulation of pathogenic alpha-synuclein (A53T) mutants through translation in the cellular system, thereby reducing the probability of disease occurrence. 20S Proteasome activator 1 can be used to study neurodegenerative diseases.

Web ID

– T63321

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H19ClF2N2OS

References

– Staerz SD, et al. Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies. J Med Chem. 2022 May 12;65(9):6631-6642.

CAS Number

– 2761578-18-9

Molecular Weight

– C27H19ClF2N2OS

Compound Purity

– 0.9968

SMILES

– C(CC(N(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2)=O)N3C=4C(SC=5C3=CC=CC5)=CC=C(Cl)C4

Pathway

– Ubiquitination|||Proteases/Proteasome

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.