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Product Description
– 2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC50=13 μM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons[1]. 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-118783
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C11H18O2
References
– [1]Yan Leng, et al. Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction. Neurosci Lett. 2010 Jun 7;476(3):127-32.
CAS Number
– 96017-59-3
Molecular Weight
– 182.26
SMILES
– CCCCCCC(CC#C)C(O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– HDAC;HSP
Pathway
– Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
Product type
– Reference compound
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