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10074-G5
$72 – $504
Products Details
Product Description
– 10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC50 of 146 μM.
Web ID
– HY-100996
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H12N4O3
References
– [1]Clausen DM, et al. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization. J Pharmacol Exp Ther. 2010 Dec;335(3):715-27.|[2]Chauhan J, et al. Discovery of methyl 4′-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization. ChemMedChem. 2014 Oct;9(10):2274-85.|[3]Yap JL, et al. Pharmacophore identification of c-Myc inhibitor 10074-G5. Bioorg Med Chem Lett. 2013 Jan 1;23(1):370-4.
CAS Number
– 413611-93-5
Molecular Weight
– 332.31
Compound Purity
– 98.52
SMILES
– O=[N+]([O-])C1=CC=C(NC2=CC=CC=C2C3=CC=CC=C3)C4=NON=C41
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 28 mg/mL
Target
– Autophagy;c-Myc
Pathway
– Apoptosis;Autophagy
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
