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Products Details
Product Description
– 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].
Web ID
– HY-124350
Shipping
– Room temperature
Molecular Formula
– C20H19N7O7
References
– [1]M D’Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2736-9.|[2]J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129(7):1315-8.
CAS Number
– 134-05-4
Molecular Weight
– 469.41
SMILES
– O=C(O)[C@@H](NC(C1=CC=C(N(C=O)CC2=NC3=C(N=C2)N=C(N)NC3=O)C=C1)=O)CCC(O)=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Antifolate;Dihydrofolate reductase (DHFR)
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
