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Products Details
Product Description
– ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II[1][2].
Web ID
– HY-131083
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C39H53N9O14S
References
– [1]Jan Grunewald, et al. Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase. WO2016071856A1.|[2]Kaya E, et al. Amanitin and phallotoxin concentration in Amanita phalloides var. alba mushroom. Toxicon. 2013;76:225-233.
CAS Number
– 21705-02-2
Molecular Weight
– 903.96
SMILES
– O=[S](C[C@H](NC(CNC1=O)=O)C(N[C@H](C2=O)CC(O)=O)=O)C(N3)=C(C[C@@H](C(NCC(N[C@H]1[C@@H](C)CC)=O)=O)NC([C@@H](NC([C@H](C4)N2C[C@@H]4O)=O)[C@@H](C)[C@@H](O)C)=O)C(C3=C5)=CC=C5O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ADC Cytotoxin;DNA/RNA Synthesis
Isoform
– Traditional Cytotoxic Agents
Pathway
– Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
