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Product Description
– β2AR/M-receptor agonist-1 (example 131) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-1 shows potency to β2 adrenoceptor with an EC50 value of 9.2 nM. β2AR/M-receptor agonist-1 also has potency to muscarinic receptor with a Ki value of 30.2 nM. β2AR/M-receptor agonist-1 shows MABA potency with an EC50 value of 4.0 nM[1].
Web ID
– HY-148524
Shipping
– Room temperature
Molecular Formula
– C43H56BrN3O7
References
– [1]WEN SHOUMING, et al. CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE. WO2018108089. 2018.
CAS Number
– 2230520-62-2
Molecular Weight
– 806.82
SMILES
– O[C@@H](C1=C2C(NC(C=C2)=O)=C(C=C1)O)CNCCCOC(C=C3)=CC=C3OCCC[N+]45C[C@H](C(CC5)CC4)OC[C@@](C6CCCC6)(C7=CC=CC=C7)O.[Br-]
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor;mAChR
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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