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β,β-Dimethylacrylshikonin
Price range: 50 CAD through 509 CAD
Products Details
Product Description
– 1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.
Web ID
– T3S2344
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H22O6
References
– Kwak S , Jeong Y , Kim B , et al. β,β-Dimethylacrylshikonin sensitizes human colon cancer cells to ionizing radiation through the upregulation of reactive oxygen species[J]. Oncology Letters, 2014.
CAS Number
– 24502-79-2
Molecular Weight
– C21H22O6
Compound Purity
– 0.9886
SMILES
– O=C1C=2C(C(=O)C=C1[C@H](OC(C=C(C)C)=O)CC=C(C)C)=C(O)C=CC2O
Pathway
– Chromatin/Epigenetic|||MAPK|||Metabolism
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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